Mikrobiota człowieka jako czynnik modulujący rozwój nowotworów – mechanizmy interakcji i perspektywy terapeutyczne

Autor

  • Dominika Nowiczkow Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

DOI:

https://doi.org/10.26881/tutg.2025.1.03

Słowa kluczowe:

mikrobiota, kancerogenność, Helicobacter pylori, immunoterapia, składniki odżywcze

Abstrakt

Od wielu milionów lat, bakterie stanowią najliczniejszą grupę organizmów żywych na Ziemi. Są one obecne wszędzie – w glebie, w powietrzu, w wodzie, a także wewnątrz organizmów żywych – w tym w nas. Można by powiedzieć, że w ludzkim organizmie wytworzył się „osobny świat”, do którego należą różnorodne mikroorganizmy – głównie bakterie, ale nie brakuje w nim też grzybów, pierwotniaków, archeonów (El-Sayed i in., 2021). W ludzkim organizmie znajdują się również wirusy, które nie są zaliczane do organizmów żywych. Populacja mikroorganizmów obecnych w danym środowisku to mikrobiota [1]. Istotnym pojęciem, często mylonym z mikrobiotą, jest mikrobiom. Mikrobiom odnosi się do całkowitego zestawu genów mikroorganizmów obecnych w danym środowisku.

Downloads

Download data is not yet available.

Bibliografia

Anderson, N. M., & Simon, M. C. (2020). The tumor microenvironment. W Current Biology (T. 30, Numer 16, s. R921–R925). Cell Press. https://doi.org/10.1016/j.cub.2020.06.081.

Bertrand, A., Kostine, M., Barnetche, T., Truchetet, M. E., & Schaeverbeke, T. (2015). Immune related adverse events associated with anti-CTLA-4 antibodies: Systematic review and meta-analysis. BMC Medicine, 13(1). https://doi.org/10.1186/s12916-015- 0455-8.

Buchta Rosean, C., Feng, T. Y., Azar, F. N., & Rutkowski, M. R. (2019). Impact of the microbiome on cancer progression and response to anti-cancer therapies. W Advances in Cancer Research (T. 143, s. 255–294). Academic Press Inc. https://doi.org/10.1016/bs.acr.2019.03.00 5.

Buseman, C. M., Wright, W. E., & Shay, J. W. (2012). Is telomerase a viable target in cancer? W Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis (T. 730, Numery 1–2, s. 90– 97). https://doi.org/10.1016/j.mrfmmm.2011.0 7.006.

Charlson, E. S., Bittinger, K., Haas, A. R., Fitzgerald, A. S., Frank, I., Yadav, A., Bushman, F. D., & Collman, R. G. (2011). Topographical continuity of bacterial populations in the healthy human respiratory tract. American Journal of Respiratory and Critical Care Medicine, 184(8), 957– 963. https://doi.org/10.1164/rccm.201104- 0655OC.

Chauhan, N., Tay, A. C. Y., Marshall, B. J., & Jain, U. (2019). Helicobacter pylori VacA, a distinct toxin exerts diverse functionalities in numerous cells: An overview. W Helicobacter (T. 24, Numer 1). Blackwell Publishing Ltd. https://doi.org/10.1111/hel.12544.

Collado, M. C., Derrien, M., Isolauri, E., De Vos, W. M., & Salminen, S. (2007). Intestinal integrity and Akkermansia muciniphila, a mucin-degrading member of the intestinal microbiota present in infants, adults, and the elderly. Applied and Environmental Microbiology, 73(23), 7767–7770. https://doi.org/10.1128/AEM.01477-07.

Cover, T. L. (2016). Helicobacter pylori diversity and gastric cancer risk. W mBio (T. 7, Numer 1). American Society for Microbiology. https://doi.org/10.1128/mBio.01869-15.

Cukic, V. (2017). The Association Between Lung Carcinoma and Tuberculosis. Medical archives (Sarajevo, Bosnia and Herzegovina), 71(3), 212–214. https://doi.org/10.5455/medarh.2017.71. 212-214.

Danuta Dzierżanowska. (2008). Antybiotykoterapia praktyczna. Alfa-Medica Press. s. 307-309.

David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., Biddinger, S. B., Dutton, R. J., & Turnbaugh, P. J. (2014). Diet rapidly and reproducibly alters the human gut microbiome. Nature, 505(7484), 559–563. https://doi.org/10.1038/nature12820.

De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010). Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proceedings of the National Academy of Sciences of the United States of America, 107(33), 14691–14696. https://doi.org/10.1073/pnas.1005963107.

de Martel, C., Georges, D., Bray, F., Ferlay, J., & Clifford, G. M. (2020). Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis. The Lancet Global Health, 8(2), e180–e190. https://doi.org/10.1016/S2214- 109X(19)30488-7.

de Vrese M, & Schrezeinmer J. (2008). Probiotics, prebiotics and synbiotics. Adv Biochem Eng Biotechnol.

Di Vincenzo, F., Del Gaudio, A., Petito, V., Lopetuso, L. R., & Scaldaferri, F. (2024). Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review. W Internal and Emergency Medicine (T. 19, Numer 2, s. 275–293). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/s11739-023- 03374-w.

Dickson, R. P., Erb-Downward, J. R., & Huffnagle, G. B. (2014). Towards an ecology of the lung: New conceptual models of pulmonary microbiology and pneumonia pathogenesis. W The Lancet Respiratory Medicine (T. 2, Numer 3, s. 238–246). Lancet Publishing Group. https://doi.org/10.1016/S2213- 2600(14)70028-1.

Earley, Z. M., Akhtar, S., Green, S. J., Naqib, A., Khan, O., Cannon, A. R., Hammer, A. M., Morris, N. L., Li, X., Eberhardt, J. M., Gamelli, R. L., Kennedy, R. H., & Choudhry, M. A. (2015). Burn injury alters the intestinal microbiome and increases gut permeability and bacterial translocation. PLoS ONE, 10(7). https://doi.org/10.1371/journal.pone.0129996.

El-Sayed, A., Aleya, L., & Kamel, M. (b.d.). Microbiota’s role in health and diseases. https://doi.org/10.1007/s11356-021- 14593-z/.

Espinoza JL, Matsumoto A, Tanaka H, & Matsmura I. (2018). Gastric microbiota: an emerging player in Helicobacter pylori-induced gastric malignancies. Cancer Lett.

Fagoonee S, & Pellicano R. (2019). Helicobacter pylori: molecular basis for colonization and survival in gastric environment and resistance to antibiotics. Infect Dis Ther., 399–408.

Fahimi F, Sarhaddi S, Fouladi M, Samadi N, Sadeghi J, & Golchin A. (2018). Phage display-derived antibody fragments against con-served regions of VacA toxin of Helicobacter pylori. Appl Microbiol Biotechnol.

Fessler, J., Matson, V., & Gajewski, T. F. (2019). Exploring the emerging role of the microbiome in cancer immunotherapy. W Journal for ImmunoTherapy of Cancer (T. 7, Numer 1). BioMed Central Ltd. https://doi.org/10.1186/s40425-019- 0574-4.

Greathouse, K. L., White, J. R., Vargas, A. J., Bliskovsky, V. V., Beck, J. A., von Muhlinen, N., Polley, E. C., Bowman, E. D., Khan, M. A., Robles, A. I., Cooks, T., Ryan, B. M., Padgett, N., Dzutsev, A. H., Trinchieri, G., Pineda, M. A., Bilke, S., Meltzer, P. S., Hokenstad, A. N., … Harris, C. C. (2018). Interaction between the microbiome and TP53 in human lung cancer. Genome Biology, 19(1). https://doi.org/10.1186/s13059-018-1501- 6.

Grice, E. A., & Segre, J. A. (2011). The skin microbiome. W Nature Reviews Microbiology (T. 9, Numer 4, s. 244–253). https://doi.org/10.1038/nrmicro2537.

Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: The next generation. W Cell (T. 144, Numer 5, s. 646–674). https://doi.org/10.1016/j.cell.2011.02.013.

Hekmatshoar, Y., Rahbar Saadat, Y., Hosseiniyan Khatibi, S. M., Ozkan, T., Zununi Vahed, F., Nariman-Saleh-Fam, Z., Pourghassem Gargari, B., Sunguroglu, A., & Zununi Vahed, S. (2019). The impact of tumor and gut microbiotas on cancer therapy: Beneficial or detrimental? W Life Sciences (T. 233). Elsevier Inc. https://doi.org/10.1016/j.lfs.2019.116680.

Jan Gawęcki. (2011). Żywienie Człowieka. Polskie Wydawnictwo Naukowe. Kay, J., Thadhani, E., Samson, L., & Engelward, B. (2019). Inflammation-induced DNA damage, mutations and cancer. W DNA Repair (T. 83). Elsevier B.V. https://doi.org/10.1016/j.dnarep.2019.102 673.

Kim, C. H. (2014). Regulation of T Cells by SCFAs. W IMMUNE NETWORK (T. 14, Numer 6).

Kobayashi, T., Glatz, M., Horiuchi, K., Kawasaki, H., Akiyama, H., Kaplan, D. H., Kong, H. H., Amagai, M., & Nagao, K. (2015). Dysbiosis and Staphyloccus aureus Colonization Drives Inflammation in Atopic Dermatitis. Immunity, 42(4), 756–766. https://doi.org/10.1016/j.immuni.2015.03.014.

Koniger V. (2016). Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA. Nat Microbiol.

Kovaleva, O. V., Romashin, D., Zborovskaya, I. B., Davydov, M. M., Shogenov, M. S., & Gratchev, A. (2019). Human Lung Microbiome on the Way to Cancer. W Journal of immunology research (T. 2019, s. 1394191). NLM (Medline). https://doi.org/10.1155/2019/1394191.

Kullander, J., Forslund, O., & Dillner, J. (2009). Staphylococcus aureus and squamous cell carcinoma of the skin. Cancer Epidemiology Biomarkers and Prevention, 18(2), 472–478. https://doi.org/10.1158/1055-9965.EPI08-0905.

Kumar Yadav, M., Kumari, I., Singh, B., Kant Sharma, K., & Kumar Tiwari, S. (b.d.). MINI-REVIEW Probiotics, prebiotics and synbiotics: Safe options for next-generation therapeutics. https://doi.org/10.1007/s00253-021- 11646-8.

Lee S. H., Sung Y, & Yong D. (2016). Characterization of microbiome in bronchoalveolar lavage fluid of patients with lung cancer comparing with benign mass like lesions. Lung Cancer.

Maleki Kakelar, H., Barzegari, A., Dehghani, J., Hanifian, S., Saeedi, N., Barar, J., & Omidi, Y. (2019). Pathogenicity of Helicobacter pylori in cancer development and impacts of vaccination. W Gastric Cancer (T. 22, Numer 1, s. 23–36). Springer Tokyo. https://doi.org/10.1007/s10120-018- 0867-1.

Matsunaga S. (2018). Alternations in metabolic pathways in gastric epithelial cells infected with Helicobacter pylori. Microb Pathog.

Mimuro, H., Suzuki, T., Tanaka, J., Asahi, M., Haas, R., & Sasakawa, C. (2002). Grb2 Is a Key Mediator of Helicobacter pylori CagA Protein Activities The intracellular CagA has been shown to undergo tyrosine (Tyr) phos. W Molecular Cell (T. 10).

Morgan, X. C., & Huttenhower, C. (2012). Chapter 12: Human Microbiome Analysis. PLoS Computational Biology, 8(12). https://doi.org/10.1371/journal.pcbi.1002808.

Nakatsuji, T., Chen, T. H., Butcher, A. M., Trzoss, L. L., Nam, S.-J., Shirakawa, K. T., Zhou, W., Oh, J., Otto, M., Fenical, W., & Gallo, R. L. (2018). H E A L T H A N D M E D I C I N E A commensal strain of Staphylococcus epidermidis protects against skin neoplasia.

Oleastro M, Cordeiro R, Ferrand J, Nunes B, Lehours P, & Carvalho-Oliviera I. (2008). Evaluation of the clinical significance of HomB a novel candidate marker of Helicobacter pylori strains associated with peptic ulcer disease. J Infect Dis.

Peterson, J., Garges, S., Giovanni, M., McInnes, P., Wang, L., Schloss, J. A., Bonazzi, V., McEwen, J. E., Wetterstrand, K. A., Deal, C., Baker, C. C., Di Francesco, V., Howcroft, T. K., Karp, R. W., Lunsford, R. D., Wellington, C. R., Belachew, T., Wright, M., Giblin, C., … Guyer, M. (2009). The NIH Human Microbiome Project. Genome Research, 19(12), 2317– 2323. https://doi.org/10.1101/gr.096651.109.

Prescott i in. (1999). Microbiology 4E. McGrawHill.

Radzisław Kordek. (2007). Onkologia. Podręcznik dla studentów i lekarzy. VIA MEDICA. s. 96 .

Randy Y. C. Poon. (2015). Cell cycle control. Module in Biomedical Sciences.

Ray, A., Moore, T. F., Pandit, R., Burke, A. D., & Borsch, D. M. (2023). An Overview of Selected Bacterial Infections in Cancer, Their Virulence Factors, and Some Aspects of Infection Management. W Biology (T. 12, Numer 7). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/biology12070963.

Ribatti, D. (2017). Oncotarget 7175 www.impactjournals.com/oncotarget The concept of immune surveillance against tumors: The first theories. W Oncotarget (T. 8, Numer 4). www.impactjournals.com/oncotarget/.

Romond M. B., Ais A, Guillemot F, Bounouader R, Cortor A, & Romond C. (1998). Cellfree whey from milk fermented with Bifidobacterium breve C50 used to modify the colonic microflora of healthy subjects. J Diary Sci. Science Photo Library. (b.d.). Human Microbiome Poster.

Sender, R., Fuchs, S., & Milo, R. (2016). Revised Estimates for the Number of Human and Bacteria Cells in the Body. PLoS Biology, 14(8). https://doi.org/10.1371/journal.pbio.1002533.

Sethi, S., & Murphy, T. F. (2001). Bacterial infection in chronic obstructive pulmonary disease in 2000: A state-of-the-art review. W Clinical Microbiology Reviews (T. 14, Numer 2, s. 336–363). https://doi.org/10.1128/CMR.14.2.336- 363.2001.

Singh, R. K., Chang, H. W., Yan, D., Lee, K. M., Ucmak, D., Wong, K., Abrouk, M., Farahnik, B., Nakamura, M., Zhu, T. H., Bhutani, T., & Liao, W. (2017). Influence of diet on the gut microbiome and implications for human health. W Journal of Translational Medicine (T. 15, Numer 1). BioMed Central Ltd. https://doi.org/10.1186/s12967-017-1175- y.

Spady D. K, Woollett L. A, & Dietschy J. M. (1993). Regulation of plasma LDLcholesterol levels by dietary cholesterol and fatty acids. Annu Rev Nutr.

Steadtke V, Roberts N. J., Bai R. Y., & Zhou S. (2016). Clostridium novyi-NT in cancer therapy. Genes dis 3.

Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss C. A, & Maza O. (2014). Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature.

Swann, J. B., & Smyth, M. J. (2007). Immune surveillance of tumors. W Journal of Clinical Investigation (T. 117, Numer 5, s. 1137– 1146). https://doi.org/10.1172/JCI31405.

Szczyrek, M., Bitkowska, P., Chunowski, P., Czuchryta, P., Krawczyk, P., & Milanowski, J. (2021). Diet, microbiome and cancer immunotherapy—a comprehensive review. W Nutrients (T. 13, Numer 7). MDPI AG. https://doi.org/10.3390/nu13072217.

Volpato, M., & Hull, M. A. (2018). Omega-3 polyunsaturated fatty acids as adjuvant therapy of colorectal cancer. Cancer and Metastasis Reviews, 37(2–3), 545–555. https://doi.org/10.1007/s10555-018- 9744-y.

Waldemar Janiec, & Jolanta Krupińska. (2002). Farmakodynamika, podręcznik dla studentów farmacji. Wydawnictwo Lekarskie PZWL. s. 916

Waleed Aziz, Z., Hashim Saleem, S., & Abdulmajeed Al-Nuaimy, H. (2019). Helicobacter pylori in Gastric biopsy: A Histochemical and Immunohistochemical Assessment (T. 41, Numer 2).

William D. James, Elston D, James R. Treat, Misha A Rosenbach, & Neuhaus I. Andrews. (2020). Diseases of the Skin: Clinical Dermatology. Elsevier.

Woo, Y. R., Cho, S. H., Lee, J. D., & Kim, H. S. (2022). The Human Microbiota and Skin Cancer. W International Journal of Molecular Sciences (T. 23, Numer 3). MDPI. https://doi.org/10.3390/ijms23031813.

Wood, D. L. A., Lachner, N., Tan, J. M., Tang, S., Angel, N., Laino, A., Linedale, R., Cao, K. A. L., Morrison, M., Frazer, I. H., Soyer, H. P., & Hugenholtz, P. (2018). A natural history of actinic keratosis and cutaneous squamous cell carcinoma microbiomes. mBio, 9(5). https://doi.org/10.1128/mBio.01432-18.

Yu, G., Gail, M. H., Consonni, D., Carugno, M., Humphrys, M., Pesatori, A. C., Caporaso, N. E., Goedert, J. J., Ravel, J., & Landi, M. T. (2016). Characterizing human lung tissue microbiota and its relationship to epidemiological and clinical features. Genome Biology, 17(1). https://doi.org/10.1186/s13059-016-1021- 1.

Zhang, X. Y., Zhang, P. Y., & Aboul-Soud, M. A. M. (2017). From inflammation to gastric cancer: Role of Helicobacter pylori. W Oncology Letters (T. 13, Numer 2, s. 543– 548). Spandidos Publications. https://doi.org/10.3892/ol.2016.5506.

Zhao, L., & Shen, J. (2010). Whole-body systems approaches for gut microbiota-targeted, preventive healthcare. Journal of Biotechnology, 149(3), 183–190. https://doi.org/10.1016/j.jbiotec.2010.02.008.

Źródła internetowe:

- https://lifescience.pl/blog/mikrobiota-i-jejwplyw-na-organizm-czlowieka/ [dostęp: grudzień 2024].

- https://www.theguardian.com/news/2018/mar/26/the-human-microbiome-why-our-microbescould-be-key-to-our-healt [dostęp: grudzień 2024] .

- http://laboratoria.net/artykul/23623.html [dostęp: grudzień 2024] .

- https://biomcare-com.translate.goog/info/key-terms-in-microbiome-projects/?_x_tr_sl=en&_x_tr_tl=pl&_x_tr_hl= pl&_x_tr_pto=rq [dostęp: grudzień 2024] .

- https://www.sonomedszczecin.pl/rakiskory/ [dostęp: grudzień 2024] .

- https://zdrowegeny.pl/poradnik/prebiotykiprobiotyk-na-jelita?gad_source=1&gbraid=0AAAAADWDaQf_7uJF dChZZHvqByJFc3kzR&gclid=Cj0KCQjwlvW2 BhDyARIsADnIe-LnHqT_gGTeMFIxoKfi04Jo61lLp2WBUqfPwX0JZlYyScMz oKnQGBsaAskzEALw_wcB [dostęp: grudzień 2024] .

- https://dietetycy.org.pl/synbiotyki/ [dostęp: grudzień 2024] .

- https://www.sarcoma.pl/baza-wiedzy/abcpacjenta-onkologicznego/wyswietl-haslo,metody-leczenia [dostęp: grudzień 2024].

Pobrania

Opublikowane

2025-04-28

Jak cytować

Nowiczkow, D. (2025). Mikrobiota człowieka jako czynnik modulujący rozwój nowotworów – mechanizmy interakcji i perspektywy terapeutyczne. Tutoring Gedanensis, 10(1), 26–42. https://doi.org/10.26881/tutg.2025.1.03

Numer

Dział

Artykuły