Uniwersyteckie Czasopisma NaukoweStar Trek: The Next Regeneration – czyli o tym, jak żaby nie są w tych tematach zielone
DOI:
https://doi.org/10.26881/tutg.2025.1.04Słowa kluczowe:
regeneracja, Xenopus laevis, terapie komórkami macierzystymiAbstrakt
Praca wskazuje szlaki sygnalizacyjne oraz czynniki transkrypcyjne i białka zaangażowane w regenerację u ludzi, aksolotli i żab Xenopus. Omówione jest działanie i wpływ na regenerację m.in. szlaków Hippo oraz Jak/Stat, genów Xetrov oraz Sox2/3, czynników takich jak melanokortyny Mc4r, interleukina 11, klf oraz udział komórek ROC. Opisane zostały drogi regeneracji kończyn, części układu nerwowego takich jak mózg, rdzeń nerwowy i nerw wzrokowy oraz narządów wewnętrznych jak serce czy wątroba u ww. organizmów . Autor wskazuje na ograniczenia regeneracji u żab Xenopus oraz porównuje umiejętności regeneracyjne człowieka. Wspomniane są aspekty ewolucyjne zaangażowane w tracenie niektórych cech przez ssaki oraz rozpatrywana jest możliwość wykorzystania umiejętności regeneracyjnych płazów i zaangażowanych w nie czynników do terapii przyszłości. Poruszona jest również tematyka obecnych nowatorskich terapii komórkowych oraz ich dalszy tor i niebezpieczeństwa z nimi związane.
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Źródła internetowe:
- https://files.poltransplant.org.pl/Biuletyn_2023_www.pdf [dostęp: październik 2024]
- https://clinicaltrials.gov/ [dostęp: październik.2024]
